Dave McKay lab publications

Search MEDLINE database for abstracts and/or most recent Dave McKay's publications. For links to individual abstracts, pdf files, and crystallographic coordinates, look under individual "projects".

2006

J. M. Caruthers, Y. Feng, D. B. McKay & S. N. Cohen
"Retention of core catalytic functions by a conserved minimal RNase E peptide that lacks the domain required for tetramer formation"
J. Biol. Chem. In press (2006).

S. Wang, Y. Hu, M. T. Overgaard, F. V. Karginov, O. C. Uhlenbeck & D. B. McKay
"The domain of the Bacillus subtilis DEAD-box helicase YxiN that is responsible for specific binding of 23S rRNA has an RNA recognition motif fold"
RNA 12, 959-967 (2006).

S. Wang, R. T. Fleming, E. M. Westbrook, P. Matsumura & D. B. McKay
"Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription"
J. Mol. Biol. 355, 798-808 (2006).

2005

F. V. Karginov, J. M. Caruthers, Y. Hu, D. B. McKay & O. C. Uhlenbeck
"YxiN is a modular protein combining a DEx(D/H) core and a specific RNA-binding domain"
J. Biol. Chem. 280, 35499-35505 (2005).

2004

E. Bitto & D. B. McKay
"Binding of phage-display-selected peptides to the periplasmic chaperone protein SurA mimics binding of unfolded outer membrane proteins"
FEBS Lett. 9568, 94-98( 2004).

A. R. Kwon, C. B. Trame & D. B. McKay
"Kinetics of protein substrate degradation by HslUV"
J. Struct. Biol. 146, 141-147 (2004).


2003

E. Bitto & D. B. McKay
"The periplasmic molecular chaperone protein SurA binds a peptide motif that is characteristic of integral outer membrane proteins"
J. Biol. Chem. 278, 49316-49322 (2003).

A. R. Kwon, B. M. Kessler, H. S. Overkleeft & D. B. McKay
"Structure and reactivity of an asymmetric complex between HslV and I-domain deleted HslU, a prokaryotic homolog of the eukaryotic proteasome"
J. Mol. Biol. 330, 185-195 (2003).

C. B. Trame & D. B. McKay
"Structure of the Yersinia enterocolitica molecular-chaperone protein SycE"
Acta Cryst. D59, 389-392 (2003).

J. E. Wedekind & D. B. McKay
"Crystal structure of the leadzyme at 1.8 A resolution: metal ion binding and the implications for catalytic mechanism and allo site ion regulation"
Biochemistry 42, 9554-9563 (2003).

2002

E. Bitto & D. B. McKay
"Crystallographic structure of SurA, a molecular chaperone that facilitates folding of outer membrane porins"
Structure 10, 1489-1498 (2002).

J. M. Caruthers & D. B. McKay
"Helicase structure and mechanism"
Curr Opin Struct Biol 12, 123-133. (2002).

M. C. Sousa, B. M. Kessler, H. S. Overkleeft & D. B. McKay
"Crystal structure of HslUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HslV by HslU"
J. Mol. Biol. 318, 779-785 (2002).

2001

C. B. Trame & D. B. McKay
"Structure of Haemophilus influenzae HslU protein in crystals with one-dimensional disorder twinning"
Acta Cryst. D57, 1079-1090 (2001).

M. C. Sousa & D. B. McKay
"Structure of Haemophilus influenzae HslV protein at 1.9 Angstrom resolution, revealing a cation binding site near the catalytic site"
Acta Cryst. D57, 1950-1954 (2001).

J. E. Wedekind, C. B. Trame, M. Dorywalska, P. Koehl, T. M. Raschke, M. McKee, D. FitzGerald, R. J. Collier & D. B. McKay
"Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity"
J. Mol. Biol. 314, 823-837 (2001).

M. C. Sousa & D. B. McKay
"Structure of the Universal Stress Protein of Haemophilus influenzae"
Structure 9, 1135-1141 (2001).

2000

M. C. Sousa, C. B. Trame, H. Tsuruta, S. M. Wilbanks, V. S. Reddy & D. B. McKay
"Crystal and solution structures of an HslUV protease-chaperone complex"
Cell 103, 633-643 (2000).

J. M. Caruthers, E. R. Johnson & D. B. McKay
"Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase"
Proc. Natl. Acad. Sci. USA 97, 13080-13085 (2000).

J. E. Wedekind & D. B. McKay
"Purification, crystallization, and x-ray diffraction analysis of small ribozymes"
In: Meth. Enzymol. (eds. J. Abelson & D. Celander) 317, 149-168 (2000).

1999

J. E. Wedekind & D. B. McKay
"Crystal structure of a lead-dependent ribozyme revealing metal binding sites relevant to catalysis"
Nature Struct. Biol. 6, 261-268 (1999).

J. E. Wedekind & D. B. McKay
"Structure and mechanism of small ribozymes"
In: The RNA World II (eds. T. C. Cech, R. Gesteland & J. Atkins) 265-286 (1999).

E. R. Johnson & D. B. McKay
"Mapping the role of active site residues for tranducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein"
Biochemistry 38, 10823-10830 (1999).

E. R. Johnson & D. B. McKay
"Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase"
RNA 5, 1524-1536 (1999).

J.-H. Ha, E. R. Johnson, D. B. McKay, M. C. Sousa, S. Takeda & S. M. Wilbanks
"Structure and mechanism of Hsp70 proteins"
In: Molecular Chaperones and Folding Catalysts. Regulation, Cellular Function and Mechanisms (eds. B. Bukau) 573-608 (1999).

1998-1997

S. M. Wilbanks & D. B. McKay
"Structural replacement of active site cations by the e-amino group of lysine in the ATPase fragment of bovine Hsc70"
Biochemistry 37, 7456-7462 (1998).

J. E. Wedekind & D. B. McKay
"Crystallographic structures of the hammerhead ribozyme: Relationship to ribozyme folding and catalysis"
In: Ann. Rev. Biophys. Biomol. Struct. (eds. R. M. Stroud) 27, 475-502 (1998).

M. C. Sousa & D. B. McKay
"The hydroxyl of threonine 13 of the bovine 70 kilodalton heat shock cognate protein is essential for transducing the ATP-induced conformational change"
Biochemistry 37, 15392-15399 (1998).

J.-H. Ha, U. Hellman, E. R. Johnson, L. Li, D. B. McKay, M. S. Sousa, S. Takeda, C. Wernstedt & S. M. Wilbanks
"Destabilization of peptide binding and inter-domain communication by an E543K mutation in the bovine seventy kilodalton heat shock cognate protein, a molecular chaperone"
J. Biol. Chem. 272, 27796-27803 (1997).

1996

S. Takeda & D. B. McKay
"Kinetics of peptide binding to the bovine 70 kDa heat shock cognate protein, a molecular chaperone"
Biochemistry 35, 4636-4644 (1996).

M. C. O'Brien, K. M. Flaherty & D. B. McKay
"Lysine 71 of the chaperone protein Hsc70 is essential for ATP hydrolysis"
J. Biol. Chem. 271, 15874-15878 (1996).

D. B. McKay
"Structure and function of a hammerhead ribozyme: an unfinished story"
RNA 2, 395-403 (1996).

J.-H. Ha, E. R. Johnson, D. B. McKay, M. C. Sousa, S. Takeda & S. M. Wilbanks
"Structure and properties of the seventy kilodalton heat shock proteins"
In: Molecular Chaperones in Proteins: Structure, Function, and Mode of Action (eds. A. Fink & Y. Goto) In press (1996).

J. Braun, S. M. Wilbanks & R. H. Scheller
"The cysteine string secretory vesicle protein activates Hsc70 ATPase"
J. Biol. Chem. 271, 25989-25993 (1996).

W. Bode, F. Grams, P. Reinemer, F. X. Gomis-Ruth, U. Baumann, D. B. McKay & W. Stocker
"The metzincin-superfamily of zinc-peptidases"
Adv Exp Med Biol 389, 1-11 (1996).

1995

W. Stocker, F. Grams, U. Baumann, P. Reinemer, F.-Z. Gomis-Ruth, D. B. McKay & W. Bode
"The metzincins--Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases"
Protein Sci. 4, 823-840 (1995).

S. M. Wilbanks, L. Chen, H. Tsuruta, K. O. Hodgson & D. B. McKay
"Solution small-angle X-ray scattering study of the molecular chaperone Hsc70 and its subfragments"
Biochemistry 34, 12095-12106 (1995).

S. M. Wilbanks & D. B. McKay
"How potassium affects the activity of the molecular chaperone Hsc70: II. Potassium binds specifically in the ATPase active site"J. Biol. Chem. 270, 2251-2257 (1995).

M. C. O'Brien & D. B. McKay
"How potassium affects the activity of the molecular chaperone Hsc70: I. Potassium is required for optimal ATPase activity"
J. Biol. Chem. 270, 2247-2250 (1995).

J.-H. Ha & D. B. McKay
"Kinetics of nucleotide-induced changes in the tryptophan fluorescence of the molecular chaperone Hsc70 and its subfragments suggest the ATP-induced conformational change follows initial ATP binding"
Biochemistry 34, 11635-11644 (1995).

D. B. McKay
"Three-dimensional structure of the hammerhead ribozyme"
In: Nucleic Acids & Molecular Biology (eds. F. Eckstein & D. M. J. Lilley) 10, 161-172 (1995).

1994

H. W. Pley, K. M. Flaherty & D. B. McKay
"Model for an RNA tertiary interaction from the structure of an intermolecular complex between a GAAA tetraloop and an RNA helix"
Nature 372, 111-113 (1994).

H. W. Pley, K. M. Flaherty & D. B. McKay
"Three-dimensional structure of a hammerhead ribozyme"
Nature 372, 68-74 (1994).

D. B. McKay, S. M. Wilbanks, K. M. Flaherty, J.-H. Ha, M. C. O'Brien & L. L. Shirvanee
"Stress-70 Proteins and their Interaction with Nucleotides"
In: Heat Shock Proteins; Structure, Function, and Regulation (eds. R. Morimoto, A. Tissieres & C. Georgopoulos) 153-177 (1994).

J.-H. Ha & D. B. McKay
"ATPase kinetics of recombinant bovine 70 kilodaltion heat shock cognate protein and its amino-terminal ATPase domain"
Biochemistry 33, 14625-14635 (1994).

K. M. Flaherty, S. M. Wilbanks, C. DeLuca-Flaherty & D. B. McKay
"Structural basis of the Hsc70 ATP hydrolytic activity. II. Structure of the active site with ADP or ATP bound to wild-type and mutant ATPase fragment."
J. Biol. Chem. 269, 12899-12907 (1994).

S. M. Wilbanks, C. DeLuca-Flaherty & D. B. McKay
"Structural basis of the Hsc70 ATP hydrolytic activity. I. Kinetic analyses of active site mutants."
J. Biol. Chem. 269, 12893-12898 (1994).

1993

S. M. Zurawski, F. Vega Jr., E. L. Doyle, B. Huyghe, K. M. Flaherty, D. B. McKay & G. Zurawski
"Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor"
EMBO J. 12, 5113-5119 (1993).

H. W. Pley, D. S. Lindes, C. DeLuca-Flaherty & D. B. McKay
"Crystals of a hammerhead ribozyme"
J. Biol. Chem. 268, 19656-19658 (1993).

M. C. O'Brien & D. B. McKay
"Threonine 204 of the chaperone protein hsc70 influences the structure of the active site but is not essential for ATP hydrolysis"
J. Biol. Chem. 268, 24323-24329 (1993).

D. B. McKay
"Structure and Mechanism of the Seventy Kilodalton Heat-Shock-Related Proteins"
In: Accessory Folding Proteins (eds. G. Lorimer) 44, 67-98 (1993).

K. M. Flaherty, S. Zozulya, L. Stryer & D. B. McKay
"Three-dimensional structure of recoverin"
Cell 75, 709-716 (1993).

U. Baumann, S. Wu, K. M. Flaherty & D. B. McKay
"Three-dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two-domain protein with a calcium-binding parallel beta roll motif"
EMBO J. 12, 3357-3364 (1993).

1992

S. Ray, S. Zozulya, G. A. Niemi, K. M. Flaherty, D. Brolley, A. M. Dizhoor, D. B. McKay, J. Hurley & L. Stryer
"Cloning, expression, and crystallization of recoverin, a calcium sensor in vision"
Proc. Natl. Acad. Sci. USA 89, 5705-5709 (1992).

D. B. McKay
"Unraveling the Structure of IL-2"
Science 257, 412-413 (1992).

D. B. McKay, M. M. Thayer, K. M. Flaherty, H. Pley & D. Benvegnu
"Crystallographic Structures of the Elastase of Pseudomonas aeruginosa"
In: Matrix Metalloproteinases and Inhibitors (eds. H. Birkedal-Hansen, Z. Werb, H. G. Welgus & H. E. Van Wart) 112-115 (1992).

D. R. Holland, D. E. Tronrud, H. W. Pley, K. M. Flaherty, W. Stark, J. N. Jansonius, D. B. McKay & B. W. Matthews
"Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis"
Biochemistry 31, 11310-11316 (1992).

1991

M. M. Thayer, K. M. Flaherty & D. B. McKay
"Three-Dimensional Structure of the Elastase of Pseudomonas aeruginosa at 1.5 Angstrom Resolution"
J. Biol. Chem. 266, 2864-2871 (1991).

D. B. McKay
"Structure of the 70-kilodalton heat-shock-related proteins"
Springer Semin. Immunopathol. 13, 1-9 (1991).

K. M. Flaherty, D. B. McKay, W. Kabsch & K. C. Holmes
"Similarity of the Three-dimensional Structures of Actin and the ATPase Fragment of a 70-kDa Heat Shock Cognate Protein"
Proc. Natl. Acad. Sci. USA 88, 5041-5045 (1991).

1990

K. M. Flaherty, C. DeLuca-Flaherty & D. B. McKay
"Three-Dimensional Structure of the ATPase Fragment of a 70 Kilodalton Heat Shock Cognate Protein"
Nature 346, 623-628 (1990).

C. DeLuca-Flaherty, D. B. McKay, P. Parham & B. L. Hill
"Uncoating Protein (hsc70) Binds a Conformationally Labile Domain of Clathrin Light Chain LCa to Stimulate ATP Hydrolysis"
Cell 62, 875-887 (1990).

D. B. McKay, V. S. Allured, B. J. Brandhuber & T. G. Falbel
"Structures of Pseudomonas and Diphtheria Toxins"
In: Trafficking of Bacterial Toxins (eds. C. B. Saelinger) 15-23 (1990).

C. DeLuca-Flaherty & D. B. McKay
"Nucleotide Sequence of the cDNA of a Bovine 70 Kilodalton Heat Shock Cognate Protein"
Nucl. Acids Res. 18, 5569-5569 (1990).

1988

C. DeLuca-Flaherty, K. M. Flaherty, L. J. McIntosh, B. Bahrami & D. B. McKay
"Crystals of an ATPase Fragment of Bovine Clathrin Uncoating ATPase"
J. Mol. Biol. 200, 749-750 (1988).

B. J. Brandhuber & D. B. McKay
"Crystallographic Studies of Pseudomonas aeruginosa Exotoxin A: Mapping the Enzymatic Active Site"
In: Third European Workshop on Bacterial Protein Toxins (eds. F. J. Fehrenbach, J. E. Alouf, P. Falmange, W. Goebel, J. Jeljaszewicz, D. Jurgens & R. Rappuoli) Supplement 17, 13-18 (1988).

B. J. Brandhuber, V. S. Allured, T. G. Falbel & D. B. McKay
"Mapping the Enzymatic Active Site of Pseudomonas aeruginosa Exotoxin A"
Proteins 3, 146-154 (1988).

1987-1985

B. J. Brandhuber, T. Boone, W. C. Kenney & D. B. McKay
"Three Dimensional Structure of Interleukin-2"
Science 238, 1707-1709 (1987).

B. J. Brandhuber, T. Boone, W. C. Kenney & D. B. McKay
"Crystals and a Low Resolution Structure of Interleukin-2"
J. Biol. Chem. 262, 12306-12308 (1987).

V. S. Allured, B. J. Brandhuber & D. B. McKay
"Structure and Mechanism of Exotoxin A of Pseudomonas aeruginosa"
In: Membrane-Mediated Cytotoxicity (eds. B. Bonavida & R. J. Collier) 45, 3-7 (1986).

V. S. Allured, R. J. Collier, S. F. Carroll & D. B. McKay
"Structure of Exotoxin A of Pseudomonas aeruginosa at 3.0 Angstrom Resolution"
Proc. Natl. Acad. Sci. USA 83, 1320-1324 (1986).

V. S. Allured, L. M. Case, S. H. Leppla & D. B. McKay
"Crystallization of the Protective Antigen Protein of Bacillus Anthracis"
J. Biol. Chem. 260, 5012-5013 (1985).

1982

R. J. Collier, E. M. Westbrook, D. B. McKay & D. Eisenberg
"X-ray Grade Crystals of Diphtheria Toxin"
J. Biol. Chem. 257, 5283-5285 (1982).

R. J. Collier & D. B. McKay
"Crystallization of Exotoxin A from Pseudomonas aeruginosa"
J. Mol. Biol. 157, 413-415 (1982).

I. T. Weber, D. B. McKay & T. A. Steitz
"Two Helix DNA Binding Motif of CAP Found in Lac Repressor and Gal Repressor"
Nucl. Acid Res. 10, 5085-5102 (1982).

D. B. McKay & K. G. Williams
"Crystallization of a Tryptic Core of the Single-stranded DNA Binding Protein of Bacteriophage T4"
J. Mol. Biol. 160, 659-661 (1982).

D. B. McKay, C. A. Pickover & T. A. Steitz
"The E. coli lac Repressor is Elongated with its Operator DNA Binding Domains Located at Both Ends"
J. Mol. Biol. 156, 175-183 (1982).

T. A. Steitz, D. H. Ohlendorf, D. B. McKay, W. F. Anderson & B. W. Matthews
"Structural Similarity in the DNA Binding Domains of Catabolite Gene Activator and Cro Repressor Proteins"
Proc. Natl. Acad. Sci. USA 79, 3097-3100 (1982).

D. B. McKay, I. T. Weber & T. A. Steitz
"Structure of Catabolite Gene Activator Protein at 2.9 A Resolution: Incorporation of Amino Acid Sequence and Interactions with Cyclic AMP"
J. Biol. Chem. 257, 9518-9524 (1982).

1981-1977

D. B. McKay & T. A. Steitz
"Structure of Catabolite Gene Activator Protein at 2.9 A Resolution Suggests Binding to Left-Handed B-DNA"
Nature 290, 744-749 (1981).

D. B. McKay, T. A. Steitz, I. T. Weber, S. C. West & P. Howard-Flanders
"Crystallization of Monomeric recA Protein"
J. Biol. Chem. 255, 6622 (1980).

D. B. McKay & M. G. Fried
"Crystallization and Preliminary X-ray Diffraction Data for the Cyclic AMP Receptor Protein of Escherichia coli"
J. Mol. Biol. 139, 95-96 (1980).

C. A. Pickover, D. B. McKay, D. M. Engelman & T. A. Steitz
"Substrate Binding Closes the Cleft Between the Domains of Yeast Phosphoglycerate Kinase"
J. Biol. Chem. 254, 11323-11329 (1979).

C. A. Hutchison Jr. & D. B. McKay
"The Determination of Hydrogen Coordinates in Lanthanum Nicotinate Dihydrate Crystals by Nd-Proton Double Resonance"
J. Chem. Phys. 66, 3311-3330 (1977).

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